Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments

Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments

Numerous anti-cancer drugs perturb thymidylate biosynthesis and lead to genomic uracil incorporation contributing to their antiproliferative effect. Still, it is not yet characterized if uracil incorporations have any positional preference. Here, we aimed to uncover genome-wide alterations in uracil...

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Bibliographic Details
Main Authors: Hajnalka L Pálinkás, Angéla Békési, Gergely Róna, Lőrinc Pongor, Gábor Papp, Gergely Tihanyi, Eszter Holub, Ádám Póti, Carolina Gemma, Simak Ali, Michael J Morten, Eli Rothenberg, Michele Pagano, Dávid Szűts, Balázs Győrffy, Beáta G Vértessy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
uracil-DNA
genome-wide mapping
U-DNA-Seq
super-resolution microscopy
anti-cancer drug treatment
Online Access:https://elifesciences.org/articles/60498

Internet

https://elifesciences.org/articles/60498

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