CRISPhieRmix: a hierarchical mixture model for CRISPR pooled screens

CRISPhieRmix: a hierarchical mixture model for CRISPR pooled screens

Abstract Pooled CRISPR screens allow researchers to interrogate genetic causes of complex phenotypes at the genome-wide scale and promise higher specificity and sensitivity compared to competing technologies. Unfortunately, two problems exist, particularly for CRISPRi/a screens: variability in guide...

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Bibliographic Details
Main Authors: Timothy P. Daley, Zhixiang Lin, Xueqiu Lin, Yanxia Liu, Wing Hung Wong, Lei S. Qi
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Genome Biology
Subjects:
CRISPR screen
CRISPR interference
CRISPR activation
sgRNA design
Mixture models
Local fdr
Online Access:http://link.springer.com/article/10.1186/s13059-018-1538-6

Internet

http://link.springer.com/article/10.1186/s13059-018-1538-6

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