Insulin-Like Growth Factor Gene Polymorphisms Predict Clinical Course in Allogeneic Hematopoietic Stem Cell Transplantation

Insulin-Like Growth Factor Gene Polymorphisms Predict Clinical Course in Allogeneic Hematopoietic Stem Cell Transplantation

Allogeneic hematopoietic stem cell transplantation (HSCT) is challenged by significant toxicities that are propagated by systemic inflammation caused by cytotoxic damage. Insulin-like growth factor-1 (IGF-1) is key in repair of most tissues and is to a large extent genetically determined. We investi...

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Bibliographic Details
Main Authors: Maria Ebbesen, Christian Enevold, Anders Juul, Carsten Heilmann, Henrik Sengeløv, Klaus Müller
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
hematopoietic stem cell transplantation
insulin-like growth factor-1
single nucleotide polymorphisms
toxicity
systemic inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01646/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01646/full

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