Tamm-Horsfall Glycoprotein Enhances PMN Phagocytosis by Binding to Cell Surface-Expressed Lactoferrin and Cathepsin G That Activates MAP Kinase Pathway

Tamm-Horsfall Glycoprotein Enhances PMN Phagocytosis by Binding to Cell Surface-Expressed Lactoferrin and Cathepsin G That Activates MAP Kinase Pathway

The molecular basis of polymorphonuclear neutrophil (PMN) phagocytosis-enhancing activity (PEA) by human purified urinary Tamm-Horsfall glyco- protein (THP) has not been elucidated. In this study, we found human THP bound to lactoferrin (LF) and cathepsin G (CG) expressed on the surface of PMN, iden...

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Bibliographic Details
Main Authors: Chia-Li Yu, Chang-Youh Tsai, Ming-Chi Lu, Cheng-Han Wu, Syue-Cian Siao, Song-Chou Hsieh, Ko-Jen Li
Format: Article
Language:English
Published: MDPI AG 2011-03-01
Series:Molecules
Subjects:
Tamm-Horsfall glycoprotein
neutrophil phagocytosis-enhancing activity
lactoferrin
cathepsin G
protein-core structure
carbohydrate-side chain
Online Access:http://www.mdpi.com/1420-3049/16/3/2119/

Internet

http://www.mdpi.com/1420-3049/16/3/2119/

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