Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphism

Introduction The angiotensin-converting enzyme (ACE) DD-genotype is associated with increased plasma and myocardial ACE-activity. The influence of the ACE insertion/deletion (I/D) polymorphism on the effects of ACE-inhibition on vascular responses has not been previously described. Materials and met...

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Main Authors: Adriaan A Voors, Peter P van Geel, Margreeth Oosterga, Hendrik Buikema, Dirk J van Veldhuisen, Wiek H van Gilst
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2004-09-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.3317/jraas.2004.029
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spelling doaj-d0e761894ee94bd39ba9e53a4d9333132021-05-02T14:43:58ZengHindawi - SAGE PublishingJournal of the Renin-Angiotensin-Aldosterone System1470-32032004-09-01510.3317/jraas.2004.029Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphismAdriaan A VoorsPeter P van GeelMargreeth OostergaHendrik BuikemaDirk J van VeldhuisenWiek H van GilstIntroduction The angiotensin-converting enzyme (ACE) DD-genotype is associated with increased plasma and myocardial ACE-activity. The influence of the ACE insertion/deletion (I/D) polymorphism on the effects of ACE-inhibition on vascular responses has not been previously described. Materials and methods In the randomised, double-blind QUinapril On Vascular ACE and Determinants of Ischemia Study (QUO VADIS), 149 patients undergoing coronary bypass surgery were randomised to receive either the ACE inhibitor, quinapril, or placebo. In 82 patients, we obtained ACE-genotype, and measured vascular responses to angiotensin II (Ang II) in left internal mammary arteries. Results In the placebo group, the mean maximal vasoconstriction to Ang II was significantly lower in patients with the DD-genotype than in those with the ID/II genotype (36.2±5.11% [n=13] vs . 55.6±4.57% [n=25]; p=0.01). In the quinapril group, the mean maximal vasoconstriction to Ang II was similar [n=8] vs . 57.7±4.07% [n=35]; p=0.85). between DD- and ID/II-genotype (59.6±9.19% Conclusions DD-genotype patients showed decreased vascular responses to Ang II but treatment with quinapril completely restored the decreased vascular response in DD-genotype patients to the same level as II/ID-genotype patients, while no effect of quinapril was demonstrated in the II/ID-genotype patients.https://doi.org/10.3317/jraas.2004.029
collection DOAJ
language English
format Article
sources DOAJ
author Adriaan A Voors
Peter P van Geel
Margreeth Oosterga
Hendrik Buikema
Dirk J van Veldhuisen
Wiek H van Gilst
spellingShingle Adriaan A Voors
Peter P van Geel
Margreeth Oosterga
Hendrik Buikema
Dirk J van Veldhuisen
Wiek H van Gilst
Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphism
Journal of the Renin-Angiotensin-Aldosterone System
author_facet Adriaan A Voors
Peter P van Geel
Margreeth Oosterga
Hendrik Buikema
Dirk J van Veldhuisen
Wiek H van Gilst
author_sort Adriaan A Voors
title Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphism
title_short Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphism
title_full Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphism
title_fullStr Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphism
title_full_unstemmed Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphism
title_sort vascular effects of quinapril completely depend on ace insertion/deletion polymorphism
publisher Hindawi - SAGE Publishing
series Journal of the Renin-Angiotensin-Aldosterone System
issn 1470-3203
publishDate 2004-09-01
description Introduction The angiotensin-converting enzyme (ACE) DD-genotype is associated with increased plasma and myocardial ACE-activity. The influence of the ACE insertion/deletion (I/D) polymorphism on the effects of ACE-inhibition on vascular responses has not been previously described. Materials and methods In the randomised, double-blind QUinapril On Vascular ACE and Determinants of Ischemia Study (QUO VADIS), 149 patients undergoing coronary bypass surgery were randomised to receive either the ACE inhibitor, quinapril, or placebo. In 82 patients, we obtained ACE-genotype, and measured vascular responses to angiotensin II (Ang II) in left internal mammary arteries. Results In the placebo group, the mean maximal vasoconstriction to Ang II was significantly lower in patients with the DD-genotype than in those with the ID/II genotype (36.2±5.11% [n=13] vs . 55.6±4.57% [n=25]; p=0.01). In the quinapril group, the mean maximal vasoconstriction to Ang II was similar [n=8] vs . 57.7±4.07% [n=35]; p=0.85). between DD- and ID/II-genotype (59.6±9.19% Conclusions DD-genotype patients showed decreased vascular responses to Ang II but treatment with quinapril completely restored the decreased vascular response in DD-genotype patients to the same level as II/ID-genotype patients, while no effect of quinapril was demonstrated in the II/ID-genotype patients.
url https://doi.org/10.3317/jraas.2004.029
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