Absence of Wdr13 Gene Predisposes Mice to Mild Social Isolation – Chronic Stress, Leading to Depression-Like Phenotype Associated With Differential Expression of Synaptic Proteins

Absence of Wdr13 Gene Predisposes Mice to Mild Social Isolation – Chronic Stress, Leading to Depression-Like Phenotype Associated With Differential Expression of Synaptic Proteins

We earlier reported that the male mice lacking the Wdr13 gene (Wdr13-/0) showed mild anxiety, better memory retention, and up-regulation of synaptic proteins in the hippocampus. With increasing evidences from parallel studies in our laboratory about the possible role of Wdr13 in stress response, we...

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Bibliographic Details
Main Authors: Shiladitya Mitra, Ghantasala S. Sameer Kumar, B. Jyothi Lakshmi, Suman Thakur, Satish Kumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Wdr13
gene environment interaction
depression
synaptic genes
Gata1
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00133/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00133/full

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