α-Lithiation and Electrophilic Substitution of 1,4,4-Trimethyl-3,4-dihydroquinolin-2-one

α-Lithiation and Electrophilic Substitution of 1,4,4-Trimethyl-3,4-dihydroquinolin-2-one

Treatment of 1,4,4-trimethyl-3,4-dihydroquinolin-2(1H)-one (2) with lithium diisopropylamide (LDA) followed by a wide range of electrophiles give the corresponding 4,4-dimethyl-3-substituted-3,4-dihydroquinolin-2-ones 3-13, providing a very mild electrophilic substitution of the 4,4-dimethyl-1,2,3,4...

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Bibliographic Details
Main Authors: Bouclé Sébastien, Guillard Jérôme, Viaud-Massuard Marie-Claude
Format: Article
Language:English
Published: MDPI AG 2010-10-01
Series:Molecules
Subjects:
tetrahydroquinoline
electrophilic substitution
anti-diabetic agents
Online Access:http://www.mdpi.com/1420-3049/15/11/7742/

Internet

http://www.mdpi.com/1420-3049/15/11/7742/

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