Force-induced unfolding of fibronectin in the extracellular matrix of living cells.

Whether mechanically unfolded fibronectin (Fn) is present within native extracellular matrix fibrils is controversial. Fn extensibility under the influence of cell traction forces has been proposed to originate either from the force-induced lengthening of an initially compact, folded quaternary stru...

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Bibliographic Details
Main Authors: Michael L Smith, Delphine Gourdon, William C Little, Kristopher E Kubow, R Andresen Eguiluz, Sheila Luna-Morris, Viola Vogel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-10-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1994993?pdf=render