Mitochondrial UQCC3 Modulates Hypoxia Adaptation by Orchestrating OXPHOS and Glycolysis in Hepatocellular Carcinoma

Mitochondrial UQCC3 Modulates Hypoxia Adaptation by Orchestrating OXPHOS and Glycolysis in Hepatocellular Carcinoma

Summary: Bioenergetic reprogramming during hypoxia adaption is critical to promote hepatocellular carcinoma (HCC) growth and progression. However, the mechanism underlying the orchestration of mitochondrial OXPHOS (oxidative phosphorylation) and glycolysis in hypoxia is not fully understood. Here, w...

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Bibliographic Details
Main Authors: Yun Yang, Guimin Zhang, Fengzhu Guo, Qiqi Li, Hui Luo, Yang Shu, Yuge Shen, Jia Gan, Lin Xu, Hanshuo Yang
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Cell Reports
Subjects:
HCC
mitochondria
hypoxia
ROS
bioenergenesis
HIF-1α
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720313292

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http://www.sciencedirect.com/science/article/pii/S2211124720313292

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