Successful use of ofatumumab in two cases of early-onset juvenile SLE with thrombocytopenia caused by a mutation in protein kinase C δ

Successful use of ofatumumab in two cases of early-onset juvenile SLE with thrombocytopenia caused by a mutation in protein kinase C δ

Abstract Background We previously described an endogamous Pakistani kindred in whom we identified a novel homozygous missense mutation in the PRKCD gene encoding for protein kinase C δ (PKCδ) as a cause of monogenic systemic lupus erythematosus (SLE). PKCδ has a role in the negative regulation of B...

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Bibliographic Details
Main Authors: Linda Lei, Sabina Muhammad, Muthana Al-Obaidi, Neil Sebire, Iek Leng Cheng, Despina Eleftheriou, Paul Brogan
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Pediatric Rheumatology Online Journal
Subjects:
Ofatumumab
Juvenile SLE
Rituximab
Protein kinase C δ deficiency
Acute tubulointerstitial nephritis
Online Access:http://link.springer.com/article/10.1186/s12969-018-0278-1

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http://link.springer.com/article/10.1186/s12969-018-0278-1

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