Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

Summary: Cellular inflammasome activation causes caspase-1 cleavage of the pore-forming protein gasdermin D (GSDMD) with subsequent pyroptotic cell death and cytokine release. Here, we clarify the ambiguous role of the related family member gasdermin E (GSDME) in this process. Inflammasome stimulati...

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Bibliographic Details
Main Authors: Bowen Zhou, Derek W. Abbott
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
cell death
interleukin-1
IL-1
inflammasome
gasdermins
gasdermin E
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721003120

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721003120

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