Prediction of Metabolite Concentrations, Rate Constants and Post-Translational Regulation Using Maximum Entropy-Based Simulations with Application to Central Metabolism of Neurospora crassa

Prediction of Metabolite Concentrations, Rate Constants and Post-Translational Regulation Using Maximum Entropy-Based Simulations with Application to Central Metabolism of Neurospora crassa

We report the application of a recently proposed approach for modeling biological systems using a maximum entropy production rate principle in lieu of having in vivo rate constants. The method is applied in four steps: (1) a new ordinary differential equation (ODE) based optimization approach based...

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Bibliographic Details
Main Authors: William R. Cannon, Jeremy D. Zucker, Douglas J. Baxter, Neeraj Kumar, Scott E. Baker, Jennifer M. Hurley, Jay C. Dunlap
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Processes
Subjects:
maximum entropy production
mass action kinetics
statistical thermodynamics
metabolism
Online Access:http://www.mdpi.com/2227-9717/6/6/63

Internet

http://www.mdpi.com/2227-9717/6/6/63

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