Effect of androgen deprivation therapy on serum levels of sclerostin, Dickkopf-1, and osteoprotegerin: a cross-sectional and longitudinal analysis

Abstract Androgen deprivation therapy (ADT) for men with prostate cancer (PCa) results in accelerated bone loss and increased risk of bone fracture. The aim of the present study was to evaluate serum bone markers—sclerostin, Dickkopf-1 (DKK-1) and osteoprotegerin (OPG), in a cohort of 88 PCa patient...

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Bibliographic Details
Main Authors: Alice Wang, Nishi Karunasinghe, Lindsay D. Plank, Shuotun Zhu, Sue Osborne, Charis Brown, Karen Bishop, Tiffany Schwass, Sofian Tijono, Michael Holmes, Jonathan Masters, Roger Huang, Christine Keven, Lynnette R. Ferguson, Ross Lawrenson
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-94090-y