Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery

Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery

Abstract RGD‐cryptophycin and isoDGR‐cryptophycin conjugates were synthetized by combining peptidomimetic integrin ligands and cryptophycin, a highly potent tubulin‐binding antimitotic agent across lysosomally cleavable Val‐Ala or uncleavable linkers. The conjugates were able to effectively inhibit...

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Bibliographic Details
Main Authors: Adina Borbély, Dr. Eduard Figueras, Ana Martins, Dr. Lizeth Bodero, Dr. André Raposo Moreira Dias, Dr. Paula López Rivas, Dr. Arianna Pina, Dr. Daniela Arosio, Dr. Paola Gallinari, Dr. Marcel Frese, Dr. Christian Steinkühler, Prof. Dr. Cesare Gennari, Prof. Dr. Umberto Piarulli, Prof. Dr. Norbert Sewald
Format: Article
Language:English
Published: Wiley-VCH 2019-06-01
Series:ChemistryOpen
Subjects:
antitumor agents
cancer
drug delivery
integrins
peptidomimetics
Online Access:https://doi.org/10.1002/open.201900110

Internet

https://doi.org/10.1002/open.201900110

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