Release of Phosphorylated HSP27 (HSPB1) from Platelets Is Accompanied with the Acceleration of Aggregation in Diabetic Patients.

We investigated the relationship between HSP27 phosphorylation and collagen-stimulated activation of platelets in patients with diabetes mellitus (DM). Platelet-rich plasma was prepared from blood of type 2 DM patients. The platelet aggregation was analyzed in size of aggregates by an aggregometer u...

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Main Authors: Haruhiko Tokuda, Gen Kuroyanagi, Masanori Tsujimoto, Yukiko Enomoto, Rie Matsushima-Nishiwaki, Takashi Onuma, Akiko Kojima, Tomoaki Doi, Kumiko Tanabe, Shigeru Akamatsu, Hiroki Iida, Shinji Ogura, Takanobu Otsuka, Toru Iwama, Takahisa Tanikawa, Kei Ishikawa, Kumi Kojima, Osamu Kozawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4457785?pdf=render