NMDA receptor mediated phosphorylation of GluR1 subunits contributes to the appearance of calcium-permeable AMPA receptors after mechanical stretch injury

NMDA receptor mediated phosphorylation of GluR1 subunits contributes to the appearance of calcium-permeable AMPA receptors after mechanical stretch injury

Alterations in neuronal cytosolic calcium is a key mediator of the traumatic brain injury (TBI) pathobiology, but less is known of the role and source of calcium in shaping early changes in synaptic receptors and neural circuits after TBI. In this study, we examined the calcium source and potential...

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Bibliographic Details
Main Authors: Jennifer Spaethling, Linda Le, David F. Meaney
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Neurobiology of Disease
Subjects:
Calcium permeable AMPA receptor
Traumatic brain injury
Glutamate receptor phosphorylation
Intracellular signaling
Synaptic NMDAR
Extrasynaptic NDMAR
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112000745

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http://www.sciencedirect.com/science/article/pii/S0969996112000745

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