Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function

Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function

A RAD51 paralog complex, RFS-1/RIP-1, is shown to control ssDNA binding and dissociation by RAD-51 differentially in the presence and absence of nucleotide cofactors. These nucleotide proofreading activities drive a preferential accumulation of RAD-51-ssDNA complexes with optimal nucleotide content.

Bibliographic Details
Main Authors: Mário Špírek, Martin R. G. Taylor, Ondrej Belan, Simon J. Boulton, Lumir Krejci
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25830-x
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spelling doaj-d49c4a80c40642788272abc5c212eb042021-09-26T11:44:54ZengNature Publishing GroupNature Communications2041-17232021-09-0112111210.1038/s41467-021-25830-xNucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament functionMário Špírek0Martin R. G. Taylor1Ondrej Belan2Simon J. Boulton3Lumir Krejci4International Clinical Research Center, St. Anne’s University Hospital in BrnoThe Francis Crick InstituteThe Francis Crick InstituteThe Francis Crick InstituteInternational Clinical Research Center, St. Anne’s University Hospital in BrnoA RAD51 paralog complex, RFS-1/RIP-1, is shown to control ssDNA binding and dissociation by RAD-51 differentially in the presence and absence of nucleotide cofactors. These nucleotide proofreading activities drive a preferential accumulation of RAD-51-ssDNA complexes with optimal nucleotide content.https://doi.org/10.1038/s41467-021-25830-x
collection DOAJ
language English
format Article
sources DOAJ
author Mário Špírek
Martin R. G. Taylor
Ondrej Belan
Simon J. Boulton
Lumir Krejci
spellingShingle Mário Špírek
Martin R. G. Taylor
Ondrej Belan
Simon J. Boulton
Lumir Krejci
Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function
Nature Communications
author_facet Mário Špírek
Martin R. G. Taylor
Ondrej Belan
Simon J. Boulton
Lumir Krejci
author_sort Mário Špírek
title Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function
title_short Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function
title_full Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function
title_fullStr Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function
title_full_unstemmed Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function
title_sort nucleotide proofreading functions by nematode rad51 paralogs facilitate optimal rad51 filament function
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-09-01
description A RAD51 paralog complex, RFS-1/RIP-1, is shown to control ssDNA binding and dissociation by RAD-51 differentially in the presence and absence of nucleotide cofactors. These nucleotide proofreading activities drive a preferential accumulation of RAD-51-ssDNA complexes with optimal nucleotide content.
url https://doi.org/10.1038/s41467-021-25830-x
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AT martinrgtaylor nucleotideproofreadingfunctionsbynematoderad51paralogsfacilitateoptimalrad51filamentfunction
AT ondrejbelan nucleotideproofreadingfunctionsbynematoderad51paralogsfacilitateoptimalrad51filamentfunction
AT simonjboulton nucleotideproofreadingfunctionsbynematoderad51paralogsfacilitateoptimalrad51filamentfunction
AT lumirkrejci nucleotideproofreadingfunctionsbynematoderad51paralogsfacilitateoptimalrad51filamentfunction
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