Comparisons of biophysical properties and bioactivities of mono-PEGylated endostatin and an endostatin analog

Comparisons of biophysical properties and bioactivities of mono-PEGylated endostatin and an endostatin analog

Abstract Background Endostatin (ES) is a well-established potent endogenous antiangiogenic factor. An ES variant, called zinc-binding protein-ES (ZBP-ES), is clinically available; however, its use is limited by rapid renal clearance and short residence time. PEGylation has been exploited to overcome...

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Bibliographic Details
Main Authors: Shan Wang, Yan Fu, Yongzhang Luo
Format: Article
Language:English
Published: BMC 2016-01-01
Series:Chinese Journal of Cancer
Subjects:
Endostatin
PEGylation
Antiangiogenic therapy
Drug design
Zinc-binding protein-endostatin
Online Access:http://link.springer.com/article/10.1186/s40880-016-0080-8

Internet

http://link.springer.com/article/10.1186/s40880-016-0080-8

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