AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD

AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD

The mitochondrial protein deacetylase sirtuin (SIRT) 3 may mediate exercise training-induced increases in mitochondrial biogenesis and improvements in reactive oxygen species (ROS) handling. We determined the requirement of AMP-activated protein kinase (AMPK) for exercise training-induced increases...

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Bibliographic Details
Main Authors: Josef eBrandauer, Marianne Agerholm Andersen, Holti eKellezi, Steve eRisis, Christian eFrøsig, Sara Gry Vienberg, Jonas Thue Treebak
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Physiology
Subjects:
AMPK
exercise training
ROS
sirt3
mitochondrial biogenesis
MnSOD
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00085/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00085/full

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