LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction
Parkinson's disease associated mutations in leucine rich repeat kinase 2 (LRRK2) impair mitochondrial function and increase the vulnerability of induced pluripotent stem cell (iPSC)-derived neural cells from patients to oxidative stress. Since mitochondrial DNA (mtDNA) damage can compromise mit...
Main Authors: | Laurie H. Sanders, Josée Laganière, Oliver Cooper, Sally K. Mak, B. Joseph Vu, Y. Anne Huang, David E. Paschon, Malini Vangipuram, Ramya Sundararajan, Fyodor D. Urnov, J. William Langston, Philip D. Gregory, H. Steve Zhang, J. Timothy Greenamyre, Ole Isacson, Birgitt Schüle |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2014-02-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S096999611300288X |
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