GNAQ and BRAF mutations show differential activation of the mTOR pathway in human transformed cells

Somatic mutations in GNAQ gene were described as being the main oncogenic activation in uveal melanomas, whereas mutations in BRAF gene have been described as a key genetic alteration that contributes to skin melanoma development. We have previously reported differential activation of the MAPK and A...

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Bibliographic Details
Main Authors: Helena Pópulo, Sandra Tavares, Alexandra Faustino, Joana B. Nunes, José Manuel Lopes, Paula Soares
Format: Article
Language:English
Published: PeerJ Inc. 2013-07-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/104.pdf