Relating multi-sequence longitudinal intensity profiles and clinical covariates in incident multiple sclerosis lesions

Relating multi-sequence longitudinal intensity profiles and clinical covariates in incident multiple sclerosis lesions

The formation of multiple sclerosis (MS) lesions is a complex process involving inflammation, tissue damage, and tissue repair — all of which are visible on structural magnetic resonance imaging (MRI) and potentially modifiable by pharmacological therapy. In this paper, we introduce two statistical...

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Bibliographic Details
Main Authors: Elizabeth M. Sweeney, Russell T. Shinohara, Blake E. Dewey, Matthew K. Schindler, John Muschelli, Daniel S. Reich, Ciprian M. Crainiceanu, Ani Eloyan
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:NeuroImage: Clinical
Subjects:
Structural magnetic resonance imaging
Multi-sequence imaging
Longitudinal study
Multiple sclerosis
Longitudinal lesion behavior
Principal component analysis and regression
Function-on-scalar regression
Expert rater trial
Biomarker
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158215300139

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http://www.sciencedirect.com/science/article/pii/S2213158215300139

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