Fetuin-a expression profile in mouse and human adipose tissue

• Main Authors: Abdelkrim Khadir, Sina Kavalakatt, Dhanya Madhu, Ali Tiss
• Format: Article
• Language: English
• Published: BMC 2020-03-01
• Series: Lipids in Health and Disease
• Subjects: Fetuin-a; Adipose tissue; Human adipose primary cells; Mouse adipose tissue
• Online Access: http://link.springer.com/article/10.1186/s12944-020-01225-7

Abstract Fetuin-A (Fet-A) was one of the first hepatokines to be reportedly linked to metabolic diseases. Fet-A was also suggested to be an adipokine, but its expression in the adipose tissue remains debatable. Here we compared the expression of Fet-A between human and mice adipose tissue biopsies as well as among human subcutaneous tissue and visceral adipose tissue primary cells, and mouse 3 T3-L1 cells at various stages of differentiation. Fet-A was expressed in mice biopsies and cells but not in human biopsies and cells, except in visceral adipose tissue primary cells following differentiation. Although the marginal expression of Fet-A in human visceral adipose tissue, a major contribution of Fet-A expression in human adipose tissue to systemic Fet-A levels is discounted, but it could indicate specific local Fet-A action in the visceral adipose tissue.