Targeting JAK-STAT Signalling Alters PsA Synovial Fibroblast Pro-Inflammatory and Metabolic Function
ObjectivesPsoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. Janus Kinase inhibitors (JAKi) have emerged as an encouraging class of drugs for the treatment of PsA. Here, we compare the effect of four JAKi on primary PsA synovial fibroblasts (PsAFLS) activation, me...
Main Authors: | Aisling O’Brien, Megan Mary Hanlon, Viviana Marzaioli, Siobhan C. Wade, Keelin Flynn, Ursula Fearon, Douglas J. Veale |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-06-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.672461/full |
Similar Items
-
STAT3 Mediates the Differential Effects of Oncostatin M and TNFα on RA Synovial Fibroblast and Endothelial Cell Function
by: Megan M. Hanlon, et al.
Published: (2019-08-01) -
From Bed to Bench and Back: TNF-α, IL-23/IL-17A, and JAK-Dependent Inflammation in the Pathogenesis of Psoriatic Synovitis
by: Ettore Silvagni, et al.
Published: (2021-06-01) -
Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups
by: Aurélie Najm, et al.
Published: (2018-12-01) -
Arthroscopic Guided Synovial Biopsies
by: Carl Kieran Orr, et al.
Published: (2021-02-01) -
Synovial Tissue Biopsy Research
by: Douglas J. Veale
Published: (2019-04-01)