Effect of mitomycin C with complex trabeculectomy for refractory glaucoma

AIM:To investigate the effect of mitomycin C combined with complex trabeculectomy in treatment of refractory glaucoma.<p>METHODS:One hundred and ten cases(122 eyes)in our hospital from January 2014 to June 2015 were divided into observation group(55 cases with 62 eyes)and control group(55 case...

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Main Authors: Ya-Li Wang, Tuo Li, Jia-Zhang Li, Qing-Song Wu
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2016-03-01
Series:Guoji Yanke Zazhi
Subjects:
Online Access:http://ies.ijo.cn/cn_publish/2016/3/201603040.pdf
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spelling doaj-d6bf79dc211d46468ed3febec36b12f32020-11-24T20:53:11ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232016-03-0116354754910.3980/j.issn.1672-5123.2016.3.40Effect of mitomycin C with complex trabeculectomy for refractory glaucomaYa-Li Wang0Tuo Li1Jia-Zhang Li2Qing-Song Wu3Department of Ophthalmology, the Central Hospital of Enshi Autonomous Prefecture, Enshi 445000,Hubei Province, ChinaDepartment of Ophthalmology, the Central Hospital of Enshi Autonomous Prefecture, Enshi 445000,Hubei Province, ChinaDepartment of Ophthalmology, the Central Hospital of Enshi Autonomous Prefecture, Enshi 445000,Hubei Province, ChinaDepartment of Ophthalmology, the Central Hospital of Enshi Autonomous Prefecture, Enshi 445000,Hubei Province, ChinaAIM:To investigate the effect of mitomycin C combined with complex trabeculectomy in treatment of refractory glaucoma.<p>METHODS:One hundred and ten cases(122 eyes)in our hospital from January 2014 to June 2015 were divided into observation group(55 cases with 62 eyes)and control group(55 cases with 60 eyes). All patients were treated with complex trabeculectomy, and patients in observation group were given mitomycin C. Before and at postoperatively 12mo, the intraocular pressure and visual acuity were examined. Before and at postoperatively 3mo, the levels of Vitamin B12(VB12), Vitamin B6(VB6), folic acid(FA), interleukin-2(IL-2)and interleukin-6(IL-6)in peripheral blood were detected by enzyme-linked immunosorbent assay(ELISA). <p>RESULTS:Preoperatively, there were no significant differences on intraocular pressure, visual acuity, VB12, VB6, FA, IL-2, IL-6 between the two groups(<i>P</i>>0.05). At postoperatively 1wk~12mo, the intraocular pressure of observation group was significantly lower than those of control group(<i>P</i><0.01), the visual acuity was higher than those of control group(<i>P</i><0.01); VB12, FA, IL-2 and IL-6 of observation group were significantly higher than those of control group(<i>P</i><0.05)at postoperatively 3mo. <p>CONCLUSION:Mitomycin C combined with complex trabeculectomy in treatment of refractory glaucoma could control intraocular pressure, improve visual acuity, and enhance the operation success rate.http://ies.ijo.cn/cn_publish/2016/3/201603040.pdfrefractory glaucomamitomycin Ccomplex trabeculectomy
collection DOAJ
language English
format Article
sources DOAJ
author Ya-Li Wang
Tuo Li
Jia-Zhang Li
Qing-Song Wu
spellingShingle Ya-Li Wang
Tuo Li
Jia-Zhang Li
Qing-Song Wu
Effect of mitomycin C with complex trabeculectomy for refractory glaucoma
Guoji Yanke Zazhi
refractory glaucoma
mitomycin C
complex trabeculectomy
author_facet Ya-Li Wang
Tuo Li
Jia-Zhang Li
Qing-Song Wu
author_sort Ya-Li Wang
title Effect of mitomycin C with complex trabeculectomy for refractory glaucoma
title_short Effect of mitomycin C with complex trabeculectomy for refractory glaucoma
title_full Effect of mitomycin C with complex trabeculectomy for refractory glaucoma
title_fullStr Effect of mitomycin C with complex trabeculectomy for refractory glaucoma
title_full_unstemmed Effect of mitomycin C with complex trabeculectomy for refractory glaucoma
title_sort effect of mitomycin c with complex trabeculectomy for refractory glaucoma
publisher Press of International Journal of Ophthalmology (IJO PRESS)
series Guoji Yanke Zazhi
issn 1672-5123
1672-5123
publishDate 2016-03-01
description AIM:To investigate the effect of mitomycin C combined with complex trabeculectomy in treatment of refractory glaucoma.<p>METHODS:One hundred and ten cases(122 eyes)in our hospital from January 2014 to June 2015 were divided into observation group(55 cases with 62 eyes)and control group(55 cases with 60 eyes). All patients were treated with complex trabeculectomy, and patients in observation group were given mitomycin C. Before and at postoperatively 12mo, the intraocular pressure and visual acuity were examined. Before and at postoperatively 3mo, the levels of Vitamin B12(VB12), Vitamin B6(VB6), folic acid(FA), interleukin-2(IL-2)and interleukin-6(IL-6)in peripheral blood were detected by enzyme-linked immunosorbent assay(ELISA). <p>RESULTS:Preoperatively, there were no significant differences on intraocular pressure, visual acuity, VB12, VB6, FA, IL-2, IL-6 between the two groups(<i>P</i>>0.05). At postoperatively 1wk~12mo, the intraocular pressure of observation group was significantly lower than those of control group(<i>P</i><0.01), the visual acuity was higher than those of control group(<i>P</i><0.01); VB12, FA, IL-2 and IL-6 of observation group were significantly higher than those of control group(<i>P</i><0.05)at postoperatively 3mo. <p>CONCLUSION:Mitomycin C combined with complex trabeculectomy in treatment of refractory glaucoma could control intraocular pressure, improve visual acuity, and enhance the operation success rate.
topic refractory glaucoma
mitomycin C
complex trabeculectomy
url http://ies.ijo.cn/cn_publish/2016/3/201603040.pdf
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AT tuoli effectofmitomycincwithcomplextrabeculectomyforrefractoryglaucoma
AT jiazhangli effectofmitomycincwithcomplextrabeculectomyforrefractoryglaucoma
AT qingsongwu effectofmitomycincwithcomplextrabeculectomyforrefractoryglaucoma
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