Serum Magnesium Level in Severe Preeclampsia and Eclampsia Undergoing Magnesium Sulfate Therapy at Chonburi Hospital
Objectives: To evaluate the level of serum magnesium in pregnant women with severe preeclampsia and eclampsia who received magnesium sulfate therapy and to determine the factors affecting nontherapeutic magnesium level at Chonburi Hospital. Study design: Prospective descriptive study. Materials a...
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The Royal Thai College of Obstetricians and Gynaecologists
2010-03-01
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doaj-d7503cd0701c4d4d9ca000c8030b95082020-11-24T22:00:43ZengThe Royal Thai College of Obstetricians and GynaecologistsThai Journal of Obstetrics and Gynaecology0857-60840857-60842010-03-01174190195Serum Magnesium Level in Severe Preeclampsia and Eclampsia Undergoing Magnesium Sulfate Therapy at Chonburi HospitalKittiporn Preedatham0Pimpika Tansupswatdikul1Department of Obstetrics and Gynaecology, Chonburi Hospital, Chonburi 20000, ThailandDepartment of Obstetrics and Gynaecology, Chonburi Hospital, Chonburi 20000, ThailandObjectives: To evaluate the level of serum magnesium in pregnant women with severe preeclampsia and eclampsia who received magnesium sulfate therapy and to determine the factors affecting nontherapeutic magnesium level at Chonburi Hospital. Study design: Prospective descriptive study. Materials and Methods: The data from 146 pregnant women with severe preeclampsia and eclampsia receiving magnesium sulfate therapy at Chonburi Hospital from October 1, 2007 to September 30, 2008 were collected. Blood sample for serum magnesium level was taken at the third hour after loading dose of magnesium sulfate. Multiple logistic regression was employed and the calculation were done on the following factors; age, body mass index (BMI), gestational age, gestational diabetes mellitus (GDM) and other underlying disease to find out the significant factors affecting nontherapeutic magnesium level. Results: The mean of serum magnesium level was 4.9+1.9 mg/dL. Only 67 patients (45.9%) were in the therapeutic range (4.8-8.4 mg/dL). The GDM was significantly associated with nontherapeutic serum magnesium level. (p=0.03) Conclusion: Magnesium sulfate is now the gold standard drug for preventing seizure in pregnant women with severe preeclampsia and eclampsia. In 54.1% of pregnant women who receiving the loading dose of magnesium sulfate 4 gm followed by a maintenance infusion of 1 gm/hr had inadequate therapeutic level, and GDM was a statistical significantly associated factor.https://tci-thaijo.org/index.php/tjog/article/download/1485/1212/severe preeclampsiaeclampsiamagnesium sulfatemagnesium sulfate serum level |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kittiporn Preedatham Pimpika Tansupswatdikul |
spellingShingle |
Kittiporn Preedatham Pimpika Tansupswatdikul Serum Magnesium Level in Severe Preeclampsia and Eclampsia Undergoing Magnesium Sulfate Therapy at Chonburi Hospital Thai Journal of Obstetrics and Gynaecology severe preeclampsia eclampsia magnesium sulfate magnesium sulfate serum level |
author_facet |
Kittiporn Preedatham Pimpika Tansupswatdikul |
author_sort |
Kittiporn Preedatham |
title |
Serum Magnesium Level in Severe Preeclampsia and Eclampsia Undergoing Magnesium Sulfate Therapy at Chonburi Hospital |
title_short |
Serum Magnesium Level in Severe Preeclampsia and Eclampsia Undergoing Magnesium Sulfate Therapy at Chonburi Hospital |
title_full |
Serum Magnesium Level in Severe Preeclampsia and Eclampsia Undergoing Magnesium Sulfate Therapy at Chonburi Hospital |
title_fullStr |
Serum Magnesium Level in Severe Preeclampsia and Eclampsia Undergoing Magnesium Sulfate Therapy at Chonburi Hospital |
title_full_unstemmed |
Serum Magnesium Level in Severe Preeclampsia and Eclampsia Undergoing Magnesium Sulfate Therapy at Chonburi Hospital |
title_sort |
serum magnesium level in severe preeclampsia and eclampsia undergoing magnesium sulfate therapy at chonburi hospital |
publisher |
The Royal Thai College of Obstetricians and Gynaecologists |
series |
Thai Journal of Obstetrics and Gynaecology |
issn |
0857-6084 0857-6084 |
publishDate |
2010-03-01 |
description |
Objectives: To evaluate the level of serum magnesium in pregnant women with severe preeclampsia and eclampsia who received magnesium sulfate therapy and to determine the factors affecting nontherapeutic magnesium level at Chonburi Hospital.
Study design: Prospective descriptive study.
Materials and Methods: The data from 146 pregnant women with severe preeclampsia and eclampsia receiving magnesium sulfate therapy at Chonburi Hospital from October 1, 2007 to September 30, 2008 were collected. Blood sample for serum magnesium level was taken at the third hour after loading dose of magnesium sulfate. Multiple logistic regression was employed and the calculation were done on the following factors; age, body mass index (BMI), gestational age, gestational diabetes mellitus (GDM) and other underlying disease to find out the significant factors affecting nontherapeutic magnesium level.
Results: The mean of serum magnesium level was 4.9+1.9 mg/dL. Only 67 patients (45.9%) were in the therapeutic range (4.8-8.4 mg/dL). The GDM was significantly associated with nontherapeutic serum magnesium level. (p=0.03)
Conclusion: Magnesium sulfate is now the gold standard drug for preventing seizure in pregnant women with severe preeclampsia and eclampsia. In 54.1% of pregnant women who receiving the loading dose of magnesium sulfate 4 gm followed by a maintenance infusion of 1 gm/hr had inadequate therapeutic level, and GDM was a statistical significantly associated factor. |
topic |
severe preeclampsia eclampsia magnesium sulfate magnesium sulfate serum level |
url |
https://tci-thaijo.org/index.php/tjog/article/download/1485/1212/ |
work_keys_str_mv |
AT kittipornpreedatham serummagnesiumlevelinseverepreeclampsiaandeclampsiaundergoingmagnesiumsulfatetherapyatchonburihospital AT pimpikatansupswatdikul serummagnesiumlevelinseverepreeclampsiaandeclampsiaundergoingmagnesiumsulfatetherapyatchonburihospital |
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