Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial
Objectives: Considering the optimal efficacy of bromelain for pain relief and wound healing, this study aimed to assess the effect of bromelain on wound healing, pain, and bleeding at the donor site following free gingival grafting (FGG). Materials and Methods: This randomized, controlled double-bl...
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Tehran University of Medical Sciences
2018-10-01
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doaj-d7c26aa8a85f4e5a9366cb276e9efe972020-11-25T03:13:31ZengTehran University of Medical SciencesFrontiers in Dentistry2676-296X2018-10-011552541Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical TrialSara Soheilifar0Mohsen Bidgoli1Amirarsalan Hooshyarfard2Armaghan Shahbazi3Farshid Vahdatinia4Fahime Khoshkhooie5Assistant Professor, Department of Periodontics, School of Dental Medicine, Hamadan University of Medical Sciences, Hamadan, IranAssistant Professor, Department of Periodontics, School of Dental Medicine, Hamadan University of Medical Sciences, Hamadan, IranPostgraduate Student, Department of Periodontics, School of Dental Medicine, Hamadan University of Medical Sciences, Hamadan, IranAssistant Professor, Department of Prosthodontics, School of Dental Medicine, Hamadan University of Medical Sciences, Hamadan, IranDental Surgeon, Dental Research Center, School of Dental Medicine, Hamadan University of Medical Sciences, Hamadan, IranPrivate Dentist, Hamadan, Iran Objectives: Considering the optimal efficacy of bromelain for pain relief and wound healing, this study aimed to assess the effect of bromelain on wound healing, pain, and bleeding at the donor site following free gingival grafting (FGG). Materials and Methods: This randomized, controlled double-blind clinical trial was performed on 26 patients with gingival recession. The patients were randomly divided into two groups of bromelain and placebo (n=13). Treatment was started on the day of surgery and was continued for 10 days. Pain, bleeding, and epithelialization at the donor site were the variables evaluated in this study using a questionnaire. The level of pain was determined using a visual analog scale (VAS) considering the number of analgesic tablets taken within 7 days postoperatively. Bleeding was determined according to the patient’s report, and epithelization was assessed by applying 3% hydrogen peroxide (H2O2) to the donor site. The donor site epithelialization was assessed at 7 and 10 days after surgery. Results: Bromelain caused a significant reduction in pain at the donor site (2.605±0.509) compared to the placebo (4.885±0.519; P<0.05). The number of donor sites with complete epithelialization was higher in the bromelain group compared to the placebo, but this difference was not statistically significant (P>0.05). The two groups were the same regarding postoperative bleeding (P>0.05). Conclusions: The results showed that oral bromelain (500 mg/day) can be effective in the reduction of pain at the donor site after FGG and may also enhance wound healing. Oral bromelain does not increase the risk of postoperative bleeding. https://jdt.tums.ac.ir/index.php/jdt/article/view/2541BromelainWound HealingTransplant Donor SiteOperative Surgical Procedure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sara Soheilifar Mohsen Bidgoli Amirarsalan Hooshyarfard Armaghan Shahbazi Farshid Vahdatinia Fahime Khoshkhooie |
spellingShingle |
Sara Soheilifar Mohsen Bidgoli Amirarsalan Hooshyarfard Armaghan Shahbazi Farshid Vahdatinia Fahime Khoshkhooie Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial Frontiers in Dentistry Bromelain Wound Healing Transplant Donor Site Operative Surgical Procedure |
author_facet |
Sara Soheilifar Mohsen Bidgoli Amirarsalan Hooshyarfard Armaghan Shahbazi Farshid Vahdatinia Fahime Khoshkhooie |
author_sort |
Sara Soheilifar |
title |
Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial |
title_short |
Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial |
title_full |
Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial |
title_fullStr |
Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial |
title_full_unstemmed |
Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial |
title_sort |
effect of oral bromelain on wound healing, pain, and bleeding at donor site following free gingival grafting: a clinical trial |
publisher |
Tehran University of Medical Sciences |
series |
Frontiers in Dentistry |
issn |
2676-296X |
publishDate |
2018-10-01 |
description |
Objectives: Considering the optimal efficacy of bromelain for pain relief and wound healing, this study aimed to assess the effect of bromelain on wound healing, pain, and bleeding at the donor site following free gingival grafting (FGG).
Materials and Methods: This randomized, controlled double-blind clinical trial was performed on 26 patients with gingival recession. The patients were randomly divided into two groups of bromelain and placebo (n=13). Treatment was started on the day of surgery and was continued for 10 days. Pain, bleeding, and epithelialization at the donor site were the variables evaluated in this study using a questionnaire. The level of pain was determined using a visual analog scale (VAS) considering the number of analgesic tablets taken within 7 days postoperatively. Bleeding was determined according to the patient’s report, and epithelization was assessed by applying 3% hydrogen peroxide (H2O2) to the donor site. The donor site epithelialization was assessed at 7 and 10 days after surgery.
Results: Bromelain caused a significant reduction in pain at the donor site (2.605±0.509) compared to the placebo (4.885±0.519; P<0.05). The number of donor sites with complete epithelialization was higher in the bromelain group compared to the placebo, but this difference was not statistically significant (P>0.05). The two groups were the same regarding postoperative bleeding (P>0.05).
Conclusions: The results showed that oral bromelain (500 mg/day) can be effective in the reduction of pain at the donor site after FGG and may also enhance wound healing. Oral bromelain does not increase the risk of postoperative bleeding.
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topic |
Bromelain Wound Healing Transplant Donor Site Operative Surgical Procedure |
url |
https://jdt.tums.ac.ir/index.php/jdt/article/view/2541 |
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