Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology

<p>Abstract</p> <p>Background</p> <p>Alzheimer’s disease (AD) is the leading cause of dementia among the elderly. Disease modifying therapies targeting Aβ that are in development have been proposed to be more effective if treatment was initiated prior to significant acc...

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Bibliographic Details
Main Authors: Das Pritam, Verbeeck Christophe, Minter Lisa, Chakrabarty Paramita, Felsenstein Kevin, Kukar Thomas, Maharvi Ghulam, Fauq Abdul, Osborne Barbara A, Golde Todd E
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Molecular Neurodegeneration
Subjects:
Aβ
Alzheimer’s disease
APP
Therapeutics
γ-secretase inhibition
Online Access:http://www.molecularneurodegeneration.com/content/7/1/39

Internet

http://www.molecularneurodegeneration.com/content/7/1/39

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