Biased Coupling to β-Arrestin of Two Common Variants of the CB2 Cannabinoid Receptor

Biased Coupling to β-Arrestin of Two Common Variants of the CB2 Cannabinoid Receptor

β-arrestins are partners of the G protein-coupled receptors (GPCRs), regulating their intracellular trafficking and signaling. Development of biased GPCR agonists, selectively targeting either G protein or β-arrestin pathways, are in the focus of interest due to their therapeutic potential in differ...

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Bibliographic Details
Main Authors: Gábor Turu, Eszter Soltész-Katona, András Dávid Tóth, Cintia Juhász, Miklós Cserző, Ádám Misák, András Balla, Marc G. Caron, László Hunyady
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Endocrinology
Subjects:
polymorphisms
biased
signaling
β-arrestin2
Q63R
L133I
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.714561/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.714561/full

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