Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity.

Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity.

Viruses have evolved a plethora of mechanisms to target host antiviral responses. Here, we propose a yet uncharacterized mechanism of immune regulation by the orthomyxovirus Thogoto virus (THOV) ML protein through engaging general transcription factor TFIIB. ML generates a TFIIB depleted nuclear env...

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Bibliographic Details
Main Authors: Darya A Haas, Arno Meiler, Katharina Geiger, Carola Vogt, Ellen Preuss, Georg Kochs, Andreas Pichlmair
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5927403?pdf=render

Internet

http://europepmc.org/articles/PMC5927403?pdf=render

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