Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells

Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells

Abstract Background We previously showed that knockdown of nuclear factor E2-related factor 2 (Nrf2) resulted in suppression of hepatitis C virus (HCV) infection. In this study, whether brusatol, an Nrf2 inhibitor, has dual anti-HCV and anticancer effects was explored. Methods The anti-HCV effect of...

Full description

Bibliographic Details
Main Authors: Yuko Murakami, Kazuo Sugiyama, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Keisuke Ojiro, Po-sung Chu, Nobuhito Taniki, Yoshimasa Saito, Toshiaki Teratani, Yuzo Koda, Takahiro Suzuki, Kyoko Saito, Masayoshi Fukasawa, Masanori Ikeda, Nobuyuki Kato, Takanori Kanai, Hidetsugu Saito
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Cancer
Subjects:
Hepatitis C virus
Hepatocellular carcinoma
Nuclear factor E2-related factor 2
Chemotherapy
Brusatol
Sorafenib
Online Access:http://link.springer.com/article/10.1186/s12885-018-4588-y

Internet

http://link.springer.com/article/10.1186/s12885-018-4588-y

Similar Items