In vivo Imaging With 18F-FDG- and 18F-Florbetaben-PET/MRI Detects Pathological Changes in the Brain of the Commonly Used 5XFAD Mouse Model of Alzheimer's Disease

In vivo Imaging With 18F-FDG- and 18F-Florbetaben-PET/MRI Detects Pathological Changes in the Brain of the Commonly Used 5XFAD Mouse Model of Alzheimer's Disease

Imaging biomarkers of Alzheimer's disease (AD) that are able to detect molecular changes in vivo and transgenic animal models mimicking AD pathologies are essential for the evaluation of new therapeutic strategies. Positron-emission tomography (PET) using either 18F-Fluorodeoxyglucose (18F-FDG)...

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Bibliographic Details
Main Authors: Timon N. Franke, Caroline Irwin, Thomas A. Bayer, Winfried Brenner, Nicola Beindorff, Caroline Bouter, Yvonne Bouter
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Medicine
Subjects:
FDG-PET
Amyloid-PET
Florbetaben
Alzheimer's disease
5XFAD Alzheimer model
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.00529/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2020.00529/full

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