Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells
BackgroundEnhanced lipogenesis plays a critical role in cell senescence via induction of expression of the mature form of sterol regulatory element binding protein 1 (SREBP1), which contributes to an increase in organellar mass, one of the indicators of senescence. We investigated the molecular mech...
Main Authors: | You-Mie Kim, Insun Song, Yong-Hak Seo, Gyesoon Yoon |
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Format: | Article |
Language: | English |
Published: |
Academya Publishing Co.
2013-12-01
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Series: | Endocrinology and Metabolism |
Subjects: | |
Online Access: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-28-297.pdf |
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