Prevalence of resistance to second-line tuberculosis drug among multidrug-resistant tuberculosis patients in Viet Nam, 2011
Introduction: Extensively drug-resistant tuberculosis (XDR-TB) represents an emerging public health problem worldwide. According to the World Health Organization, an estimated 9.7% of multidrug-resistant TB (MDR-TB) cases are defined as XDR-TB globally. The objective of this study was to determine t...
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doaj-da0d2881285b4195932d172048e898552021-03-02T03:37:21ZengWorld Health Organization Regional Office for the Western PacificWestern Pacific Surveillance and Response2094-73212094-73132016-06-0172354010.5365/wpsar.2016.7.2.002Prevalence of resistance to second-line tuberculosis drug among multidrug-resistant tuberculosis patients in Viet Nam, 2011Hoa Binh Nguyen0Nhung Viet Nguyen1Huong Thi Giang Tran2Hai Viet Nguyen3Quyen Thi Tu Bui4National Tuberculosis Control Programme Viet Nam, Hanoi, Viet Nam and Centre for Operational Research, International Union Against Tuberculosis and Lung Disease, Paris, FranceNational Tuberculosis Control Programme Viet Nam and Viet Nam Association for Tuberculosis and Lung Disease, Hanoi, Viet NamMinistry of Health, Department of International Cooperation, Viet NamHanoi Medical University, Hanoi, Viet NamHanoi School of Public Health, Hanoi, Viet NamIntroduction: Extensively drug-resistant tuberculosis (XDR-TB) represents an emerging public health problem worldwide. According to the World Health Organization, an estimated 9.7% of multidrug-resistant TB (MDR-TB) cases are defined as XDR-TB globally. The objective of this study was to determine the prevalence of drug resistance to second-line TB drugs among MDR-TB cases detected in the Fourth National Anti-Tuberculosis Drug Resistance Survey in Viet Nam. Methods: Eighty clusters of TB cases were selected using a probability-proportion-to-size approach. To identify MDR-TB cases, drug susceptibility testing (DST) was performed for the four major first-line TB drugs. DST of second-line drugs (ofloxacin, amikacin, kanamycin, capreomycin) was performed on isolates from MDR-TB cases to identify pre-XDR and XDR cases. Results: A total of 1629 smear-positive TB cases were eligible for culture and DST. Of those, DST results for first-line drugs were available for 1312 cases, and 91 (6.9%) had MDR-TB. Second-line DST results were available for 84 of these cases. Of those, 15 cases (17.9%) had ofloxacin resistance and 6.0% were resistant to kanamycin and capreomycin. Five MDR-TB cases (6.0%) met the criteria of XDR-TB. Conclusion: This survey provides the first estimates of the proportion of XDR-TB among MDR-TB cases in Viet Nam and provides important information for local policies regarding second-line DST. Local policies and programmes that are geared towards TB prevention, early diagnosis and treatment with effective regimens are of high importance. http://ojs.wpro.who.int/ojs/index.php/wpsar/article/view/433/676tuberculosissecond-line TB drugXDR-TBMDR-TB |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hoa Binh Nguyen Nhung Viet Nguyen Huong Thi Giang Tran Hai Viet Nguyen Quyen Thi Tu Bui |
spellingShingle |
Hoa Binh Nguyen Nhung Viet Nguyen Huong Thi Giang Tran Hai Viet Nguyen Quyen Thi Tu Bui Prevalence of resistance to second-line tuberculosis drug among multidrug-resistant tuberculosis patients in Viet Nam, 2011 Western Pacific Surveillance and Response tuberculosis second-line TB drug XDR-TB MDR-TB |
author_facet |
Hoa Binh Nguyen Nhung Viet Nguyen Huong Thi Giang Tran Hai Viet Nguyen Quyen Thi Tu Bui |
author_sort |
Hoa Binh Nguyen |
title |
Prevalence of resistance to second-line tuberculosis drug among multidrug-resistant tuberculosis patients in Viet Nam, 2011 |
title_short |
Prevalence of resistance to second-line tuberculosis drug among multidrug-resistant tuberculosis patients in Viet Nam, 2011 |
title_full |
Prevalence of resistance to second-line tuberculosis drug among multidrug-resistant tuberculosis patients in Viet Nam, 2011 |
title_fullStr |
Prevalence of resistance to second-line tuberculosis drug among multidrug-resistant tuberculosis patients in Viet Nam, 2011 |
title_full_unstemmed |
Prevalence of resistance to second-line tuberculosis drug among multidrug-resistant tuberculosis patients in Viet Nam, 2011 |
title_sort |
prevalence of resistance to second-line tuberculosis drug among multidrug-resistant tuberculosis patients in viet nam, 2011 |
publisher |
World Health Organization Regional Office for the Western Pacific |
series |
Western Pacific Surveillance and Response |
issn |
2094-7321 2094-7313 |
publishDate |
2016-06-01 |
description |
Introduction: Extensively drug-resistant tuberculosis (XDR-TB) represents an emerging public health problem worldwide. According to the World Health Organization, an estimated 9.7% of multidrug-resistant TB (MDR-TB) cases are defined as XDR-TB globally. The objective of this study was to determine the prevalence of drug resistance to second-line TB drugs among MDR-TB cases detected in the Fourth National Anti-Tuberculosis Drug Resistance Survey in Viet Nam.
Methods: Eighty clusters of TB cases were selected using a probability-proportion-to-size approach. To identify MDR-TB cases, drug susceptibility testing (DST) was performed for the four major first-line TB drugs. DST of second-line drugs (ofloxacin, amikacin, kanamycin, capreomycin) was performed on isolates from MDR-TB cases to identify pre-XDR and XDR cases.
Results: A total of 1629 smear-positive TB cases were eligible for culture and DST. Of those, DST results for first-line drugs were available for 1312 cases, and 91 (6.9%) had MDR-TB. Second-line DST results were available for 84 of these cases. Of those, 15 cases (17.9%) had ofloxacin resistance and 6.0% were resistant to kanamycin and capreomycin. Five MDR-TB cases (6.0%) met the criteria of XDR-TB.
Conclusion: This survey provides the first estimates of the proportion of XDR-TB among MDR-TB cases in Viet Nam and provides important information for local policies regarding second-line DST. Local policies and programmes that are geared towards TB prevention, early diagnosis and treatment with effective regimens are of high importance.
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topic |
tuberculosis second-line TB drug XDR-TB MDR-TB |
url |
http://ojs.wpro.who.int/ojs/index.php/wpsar/article/view/433/676 |
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