MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor

MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor

Multidrug resistance (MDR) is the main obstacle to current chemotherapy and it is mainly due to the overexpression of some efflux transporters such as MRP1. One of the most studied strategies to overcome MDR has been the inhibition of MDR pumps through small molecules, but its translation into the c...

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Bibliographic Details
Main Authors: Chiara Riganti, Roberta Giampietro, Joanna Kopecka, Costanzo Costamagna, Francesca Serena Abatematteo, Marialessandra Contino, Carmen Abate
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
collateral sensitivity
MDR
MRP1
resistant tumors
lung tumors
ROS
Online Access:https://www.mdpi.com/1422-0067/21/9/3333

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https://www.mdpi.com/1422-0067/21/9/3333

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