No seasonal accumulation of resistant P. falciparum when high-dose chloroquine is used.

Potentially chloroquine resistant P. falciparum, identified by the 76T haplotype in the chloroquine resistance transporter (pfcrt 76T), are highly prevalent throughout Africa. In Guinea-Bissau, normal and double dose chloroquine have respective efficacies of 34% and 78% against P.falciparum with pfc...

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Bibliographic Details
Main Authors: Johan Ursing, Poul-Erik Kofoed, Amabelia Rodrigues, Lars Rombo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2729929?pdf=render