Designing and testing broadly-protective filoviral vaccines optimized for cytotoxic T-lymphocyte epitope coverage.

Designing and testing broadly-protective filoviral vaccines optimized for cytotoxic T-lymphocyte epitope coverage.

We report the rational design and in vivo testing of mosaic proteins for a polyvalent pan-filoviral vaccine using a computational strategy designed for the Human Immunodeficiency Virus type 1 (HIV-1) but also appropriate for Hepatitis C virus (HCV) and potentially other diverse viruses. Mosaics are...

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Bibliographic Details
Main Authors: Paul W Fenimore, Majidat A Muhammad, William M Fischer, Brian T Foley, Russell R Bakken, James R Thurmond, Karina Yusim, Hyejin Yoon, Michael Parker, Mary Kate Hart, John M Dye, Bette Korber, Carla Kuiken
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3463593?pdf=render

Internet

http://europepmc.org/articles/PMC3463593?pdf=render

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