Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system

Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system

Abstract Background Increasing evidence supports a key role for inflammation in the neurodegenerative process of familial amyloidotic polyneuropathy (FAP). While there seems to be an overactivation of the neuronal interleukin-1 signaling pathway, the immune response is apparently compromised in FAP....

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Bibliographic Details
Main Authors: Nádia Pereira Gonçalves, João Moreira, Diana Martins, Paulo Vieira, Laura Obici, Giampaolo Merlini, Margarida Saraiva, Maria João Saraiva
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Neuroinflammation
Subjects:
Cathepsin E
Transthyretin
Immune regulation
Macrophages
Neurodegeneration
Familial amyloidotic polyneuropathy
Online Access:http://link.springer.com/article/10.1186/s12974-017-0891-9

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http://link.springer.com/article/10.1186/s12974-017-0891-9

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