Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury

Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury

Background & Aims: Mitochondria are the major organelles for the formation of reactive oxygen species (ROS) in the cell, and mitochondrial dysfunction has been described as a key factor in the pathogenesis of cholestatic liver disease. The methylation-controlled J-protein (MCJ) is a mitochon...

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Main Authors: Paula Iruzubieta, Naroa Goikoetxea-Usandizaga, Lucía Barbier-Torres, Marina Serrano-Maciá, David Fernández-Ramos, Pablo Fernández-Tussy, Virginia Gutiérrez-de-Juan, Sofia Lachiondo-Ortega, Jorge Simon, Miren Bravo, Fernando Lopitz-Otsoa, Mercedes Robles, Carlos Ferre-Aracil, Marta Varela-Rey, Natalia Elguezabal, José Luis Calleja, Shelly C. Lu, Malgorzata Milkiewicz, Piotr Milkiewicz, Juan Anguita, María J. Monte, José J.G. Marin, Marcos López-Hoyos, Teresa C. Delgado, Mercedes Rincón, Javier Crespo, María Luz Martínez-Chantar
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:JHEP Reports
Subjects:
Cholestasis
Mitochondria
MCJ
ROS
Bile duct ligation
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555921000525

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http://www.sciencedirect.com/science/article/pii/S2589555921000525

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