New peptides players in metabolic disorders
Among new peptides responsible for the pathogenesis of metabolic disorders and carbohydrate metabolism, adipokines are of great importance. Adipokines are substances of hormonal character, secreted by adipose tissue. Apart from the well-known adipokines, adropin and preptin are relatively newly disc...
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2016-08-01
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doaj-db5b784d36394506a6151016544d45f82020-11-24T20:41:16ZengIndex Copernicus International S.A.Postępy Higieny i Medycyny Doświadczalnej0032-54491732-26932016-08-017088188610.5604/01.3001.0009.686601.3001.0009.6866New peptides players in metabolic disordersAgata Mierzwicka0Marek Bolanowski1Katedra i Klinika Endokrynologii, Diabetologii i Leczenia Izotopami, Uniwersytet Medyczny im. Piastów Śląskich we WrocławiuKatedra i Klinika Endokrynologii, Diabetologii i Leczenia Izotopami, Uniwersytet Medyczny im. Piastów Śląskich we WrocławiuAmong new peptides responsible for the pathogenesis of metabolic disorders and carbohydrate metabolism, adipokines are of great importance. Adipokines are substances of hormonal character, secreted by adipose tissue. Apart from the well-known adipokines, adropin and preptin are relatively newly discovered, hence their function is not fully understood. They are peptides not secreted by adipose tissue but their role in the metabolic regulations seems to be significant. Preptin is a 34-amino acid peptide, a derivative of proinsulin growth factor II (pro-IGF-II), secreted by pancreatic β cells, considered to be a physiological enhancer of insulin secretion. Additionally, preptin has a stimulating effect on osteoblasts, inducing their proliferation, differentiation and survival. Adropin is a 76-amino acid peptide, encoded by the energy homeostasis associated gene (Enho), mainly in liver and brain, and its expression is dependent on a diet. Adropin is believed to play an important role in metabolic homeostasis, fatty acids metabolism control, insulin resistance prevention, dyslipidemia, and impaired glucose tolerance. The results of studies conducted so far show that the diseases resulting from metabolic syndrome, such as obesity, type 2 diabetes mellitus, polycystic ovary syndrome, non-alcoholic fatty liver disease, or cardiovascular disease are accompanied by significant changes in the concentration of these peptides. It is also important to note that preptin has an anabolic effect on bone tissue, which might be preventive in osteoporosis. http://phmd.pl/gicid/01.3001.0009.6866preptynaadropinazespół metabolicznyinsulinoopornośćpreptinadropin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Agata Mierzwicka Marek Bolanowski |
spellingShingle |
Agata Mierzwicka Marek Bolanowski New peptides players in metabolic disorders Postępy Higieny i Medycyny Doświadczalnej preptyna adropina zespół metaboliczny insulinooporność preptin adropin |
author_facet |
Agata Mierzwicka Marek Bolanowski |
author_sort |
Agata Mierzwicka |
title |
New peptides players in metabolic disorders |
title_short |
New peptides players in metabolic disorders |
title_full |
New peptides players in metabolic disorders |
title_fullStr |
New peptides players in metabolic disorders |
title_full_unstemmed |
New peptides players in metabolic disorders |
title_sort |
new peptides players in metabolic disorders |
publisher |
Index Copernicus International S.A. |
series |
Postępy Higieny i Medycyny Doświadczalnej |
issn |
0032-5449 1732-2693 |
publishDate |
2016-08-01 |
description |
Among new peptides responsible for the pathogenesis of metabolic disorders and carbohydrate metabolism, adipokines are of great importance. Adipokines are substances of hormonal character, secreted by adipose tissue. Apart from the well-known adipokines, adropin and preptin are relatively newly discovered, hence their function is not fully understood. They are peptides not secreted by adipose tissue but their role in the metabolic regulations seems to be significant. Preptin is a 34-amino acid peptide, a derivative of proinsulin growth factor II (pro-IGF-II), secreted by pancreatic β cells, considered to be a physiological enhancer of insulin secretion. Additionally, preptin has a stimulating effect on osteoblasts, inducing their proliferation, differentiation and survival. Adropin is a 76-amino acid peptide, encoded by the energy homeostasis associated gene (Enho), mainly in liver and brain, and its expression is dependent on a diet. Adropin is believed to play an important role in metabolic homeostasis, fatty acids metabolism control, insulin resistance prevention, dyslipidemia, and impaired glucose tolerance. The results of studies conducted so far show that the diseases resulting from metabolic syndrome, such as obesity, type 2 diabetes mellitus, polycystic ovary syndrome, non-alcoholic fatty liver disease, or cardiovascular disease are accompanied by significant changes in the concentration of these peptides. It is also important to note that preptin has an anabolic effect on bone tissue, which might be preventive in osteoporosis.
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topic |
preptyna adropina zespół metaboliczny insulinooporność preptin adropin |
url |
http://phmd.pl/gicid/01.3001.0009.6866 |
work_keys_str_mv |
AT agatamierzwicka newpeptidesplayersinmetabolicdisorders AT marekbolanowski newpeptidesplayersinmetabolicdisorders |
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1716825819682177024 |