New peptides players in metabolic disorders

Among new peptides responsible for the pathogenesis of metabolic disorders and carbohydrate metabolism, adipokines are of great importance. Adipokines are substances of hormonal character, secreted by adipose tissue. Apart from the well-known adipokines, adropin and preptin are relatively newly disc...

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Main Authors: Agata Mierzwicka, Marek Bolanowski
Format: Article
Language:English
Published: Index Copernicus International S.A. 2016-08-01
Series:Postępy Higieny i Medycyny Doświadczalnej
Subjects:
Online Access:http://phmd.pl/gicid/01.3001.0009.6866
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spelling doaj-db5b784d36394506a6151016544d45f82020-11-24T20:41:16ZengIndex Copernicus International S.A.Postępy Higieny i Medycyny Doświadczalnej0032-54491732-26932016-08-017088188610.5604/01.3001.0009.686601.3001.0009.6866New peptides players in metabolic disordersAgata Mierzwicka0Marek Bolanowski1Katedra i Klinika Endokrynologii, Diabetologii i Leczenia Izotopami, Uniwersytet Medyczny im. Piastów Śląskich we WrocławiuKatedra i Klinika Endokrynologii, Diabetologii i Leczenia Izotopami, Uniwersytet Medyczny im. Piastów Śląskich we WrocławiuAmong new peptides responsible for the pathogenesis of metabolic disorders and carbohydrate metabolism, adipokines are of great importance. Adipokines are substances of hormonal character, secreted by adipose tissue. Apart from the well-known adipokines, adropin and preptin are relatively newly discovered, hence their function is not fully understood. They are peptides not secreted by adipose tissue but their role in the metabolic regulations seems to be significant. Preptin is a 34-amino acid peptide, a derivative of proinsulin growth factor II (pro-IGF-II), secreted by pancreatic β cells, considered to be a physiological enhancer of insulin secretion. Additionally, preptin has a stimulating effect on osteoblasts, inducing their proliferation, differentiation and survival. Adropin is a 76-amino acid peptide, encoded by the energy homeostasis associated gene (Enho), mainly in liver and brain, and its expression is dependent on a diet. Adropin is believed to play an important role in metabolic homeostasis, fatty acids metabolism control, insulin resistance prevention, dyslipidemia, and impaired glucose tolerance. The results of studies conducted so far show that the diseases resulting from metabolic syndrome, such as obesity, type 2 diabetes mellitus, polycystic ovary syndrome, non-alcoholic fatty liver disease, or cardiovascular disease are accompanied by significant changes in the concentration of these peptides. It is also important to note that preptin has an anabolic effect on bone tissue, which might be preventive in osteoporosis. http://phmd.pl/gicid/01.3001.0009.6866preptynaadropinazespół metabolicznyinsulinoopornośćpreptinadropin
collection DOAJ
language English
format Article
sources DOAJ
author Agata Mierzwicka
Marek Bolanowski
spellingShingle Agata Mierzwicka
Marek Bolanowski
New peptides players in metabolic disorders
Postępy Higieny i Medycyny Doświadczalnej
preptyna
adropina
zespół metaboliczny
insulinooporność
preptin
adropin
author_facet Agata Mierzwicka
Marek Bolanowski
author_sort Agata Mierzwicka
title New peptides players in metabolic disorders
title_short New peptides players in metabolic disorders
title_full New peptides players in metabolic disorders
title_fullStr New peptides players in metabolic disorders
title_full_unstemmed New peptides players in metabolic disorders
title_sort new peptides players in metabolic disorders
publisher Index Copernicus International S.A.
series Postępy Higieny i Medycyny Doświadczalnej
issn 0032-5449
1732-2693
publishDate 2016-08-01
description Among new peptides responsible for the pathogenesis of metabolic disorders and carbohydrate metabolism, adipokines are of great importance. Adipokines are substances of hormonal character, secreted by adipose tissue. Apart from the well-known adipokines, adropin and preptin are relatively newly discovered, hence their function is not fully understood. They are peptides not secreted by adipose tissue but their role in the metabolic regulations seems to be significant. Preptin is a 34-amino acid peptide, a derivative of proinsulin growth factor II (pro-IGF-II), secreted by pancreatic β cells, considered to be a physiological enhancer of insulin secretion. Additionally, preptin has a stimulating effect on osteoblasts, inducing their proliferation, differentiation and survival. Adropin is a 76-amino acid peptide, encoded by the energy homeostasis associated gene (Enho), mainly in liver and brain, and its expression is dependent on a diet. Adropin is believed to play an important role in metabolic homeostasis, fatty acids metabolism control, insulin resistance prevention, dyslipidemia, and impaired glucose tolerance. The results of studies conducted so far show that the diseases resulting from metabolic syndrome, such as obesity, type 2 diabetes mellitus, polycystic ovary syndrome, non-alcoholic fatty liver disease, or cardiovascular disease are accompanied by significant changes in the concentration of these peptides. It is also important to note that preptin has an anabolic effect on bone tissue, which might be preventive in osteoporosis.
topic preptyna
adropina
zespół metaboliczny
insulinooporność
preptin
adropin
url http://phmd.pl/gicid/01.3001.0009.6866
work_keys_str_mv AT agatamierzwicka newpeptidesplayersinmetabolicdisorders
AT marekbolanowski newpeptidesplayersinmetabolicdisorders
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