Issues in Localization of brain function: The case of lateralized frontal cortex in cognition, emotion, and psychopathology
The appeal of simple, sweeping portraits of large-scale brain mechanisms relevant to psychological phenomena competes with a rich, complex research base. As a prominent example, two views of frontal brain organization have emphasized dichotomous lateralization as a function of either emotional valen...
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doaj-dbbd5b34d5c94b22be2c0e9f45df48312020-11-24T22:39:32ZengFrontiers Media S.A.Frontiers in Integrative Neuroscience1662-51452013-01-01710.3389/fnint.2013.0000231550Issues in Localization of brain function: The case of lateralized frontal cortex in cognition, emotion, and psychopathologyGregory A. Miller0Gregory A. Miller1Gregory A. Miller2Laura D Crocker3Jeffrey M. Spielberg4Zachary P. Infantolino5Wendy eHeller6University of DelawareUniversity of Illinois at Urbana-ChampaignUniversity of KonstanzUniversity of Illinois at Urbana-ChampaignUniversity of California, BerkeleyUniversity of DelawareUniversity of Illinois at Urbana-ChampaignThe appeal of simple, sweeping portraits of large-scale brain mechanisms relevant to psychological phenomena competes with a rich, complex research base. As a prominent example, two views of frontal brain organization have emphasized dichotomous lateralization as a function of either emotional valence (positive/negative) or approach/avoidance motivation. Compelling findings support each. The literature has struggled to choose between them for three decades, without success. Both views are proving untenable as comprehensive models. Recent evidence indicates that positive valence and approach motivation are associated with different areas in the left hemisphere. Evidence of other frontal lateralizations, involving distinctions among dimensions of depression and anxiety, make a dichotomous view even more problematic. Hemodynamic and electromagnetic neuroimaging studies suggest considerable functional differentiation, in specialization and activation, of subregions of frontal cortex, including their connectivity to each other and to other regions. Such findings contribute to a more nuanced understanding of functional localization that accommodates aspects of multiple theoretical perspectives.http://journal.frontiersin.org/Journal/10.3389/fnint.2013.00002/fullMotivationemotionfrontal cortexlateralizationlocalization |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gregory A. Miller Gregory A. Miller Gregory A. Miller Laura D Crocker Jeffrey M. Spielberg Zachary P. Infantolino Wendy eHeller |
spellingShingle |
Gregory A. Miller Gregory A. Miller Gregory A. Miller Laura D Crocker Jeffrey M. Spielberg Zachary P. Infantolino Wendy eHeller Issues in Localization of brain function: The case of lateralized frontal cortex in cognition, emotion, and psychopathology Frontiers in Integrative Neuroscience Motivation emotion frontal cortex lateralization localization |
author_facet |
Gregory A. Miller Gregory A. Miller Gregory A. Miller Laura D Crocker Jeffrey M. Spielberg Zachary P. Infantolino Wendy eHeller |
author_sort |
Gregory A. Miller |
title |
Issues in Localization of brain function: The case of lateralized frontal cortex in cognition, emotion, and psychopathology |
title_short |
Issues in Localization of brain function: The case of lateralized frontal cortex in cognition, emotion, and psychopathology |
title_full |
Issues in Localization of brain function: The case of lateralized frontal cortex in cognition, emotion, and psychopathology |
title_fullStr |
Issues in Localization of brain function: The case of lateralized frontal cortex in cognition, emotion, and psychopathology |
title_full_unstemmed |
Issues in Localization of brain function: The case of lateralized frontal cortex in cognition, emotion, and psychopathology |
title_sort |
issues in localization of brain function: the case of lateralized frontal cortex in cognition, emotion, and psychopathology |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Integrative Neuroscience |
issn |
1662-5145 |
publishDate |
2013-01-01 |
description |
The appeal of simple, sweeping portraits of large-scale brain mechanisms relevant to psychological phenomena competes with a rich, complex research base. As a prominent example, two views of frontal brain organization have emphasized dichotomous lateralization as a function of either emotional valence (positive/negative) or approach/avoidance motivation. Compelling findings support each. The literature has struggled to choose between them for three decades, without success. Both views are proving untenable as comprehensive models. Recent evidence indicates that positive valence and approach motivation are associated with different areas in the left hemisphere. Evidence of other frontal lateralizations, involving distinctions among dimensions of depression and anxiety, make a dichotomous view even more problematic. Hemodynamic and electromagnetic neuroimaging studies suggest considerable functional differentiation, in specialization and activation, of subregions of frontal cortex, including their connectivity to each other and to other regions. Such findings contribute to a more nuanced understanding of functional localization that accommodates aspects of multiple theoretical perspectives. |
topic |
Motivation emotion frontal cortex lateralization localization |
url |
http://journal.frontiersin.org/Journal/10.3389/fnint.2013.00002/full |
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