Deleterious Variants in <i>WNT10A</i>, <i>EDAR,</i> and <i>EDA</i> Causing Isolated and Syndromic Tooth Agenesis: A Structural Perspective from Molecular Dynamics Simulations

Deleterious Variants in <i>WNT10A</i>, <i>EDAR,</i> and <i>EDA</i> Causing Isolated and Syndromic Tooth Agenesis: A Structural Perspective from Molecular Dynamics Simulations

The dental abnormalities are the typical features of many ectodermal dysplasias along with congenital malformations of nails, skin, hair, and sweat glands. However, several reports of non-syndromic/isolated tooth agenesis have also been found in the literature. The characteristic features of hypohid...

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Bibliographic Details
Main Authors: Asia Parveen, Sher Alam Khan, Muhammad Usman Mirza, Hina Bashir, Fatima Arshad, Maria Iqbal, Waseem Ahmad, Ahsan Wahab, Amal Fiaz, Sidra Naz, Fareeha Ashraf, Tayyaba Mobeen, Salman Aziz, Syed Shoaib Ahmed, Noor Muhammad, Nehal F. Hassib, Mostafa I. Mostafa, Nagwa E. Gaboon, Roquyya Gul, Saadullah Khan, Matheus Froeyen, Muhammad Shoaib, Naveed Wasif
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
hypodontia/oligodontia
hypohidrotic ectodermal dysplasia
<i>wnt10a</i>
<i>edar</i>
<i>eda</i>
exome sequencing
md simulations
Online Access:https://www.mdpi.com/1422-0067/20/21/5282

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https://www.mdpi.com/1422-0067/20/21/5282

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