Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease

Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease

Amyotrophic lateral sclerosis (ALS) and motor neuron diseases (MNDs) are progressive neurodegenerative diseases that affect nerve cells in the brain affecting upper and lower motor neurons (UMNs/LMNs), brain stem and spinal cord. The clinical phenotype is characterized by loss of motor neurons (MNs)...

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Bibliographic Details
Main Author: Manoj Kumar Jaiswal
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Neural Regeneration Research
Subjects:
iPSCs; stem cells; human patients; ALS; mitochondria; motor neuron disease; disease modeling; neurodegeneration; gene editing; transplantation; drug screening
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=5;spage=723;epage=736;aulast=Jaiswal

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=5;spage=723;epage=736;aulast=Jaiswal

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