Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming

Among gynecologic malignancies, ovarian cancer is the third most prevalent and the most common cause of death, especially due to diagnosis at an advanced stage together with resistance to therapy. As a solid tumor grows, cancer cells in the microenvironment are exposed to regions of hypoxia, a selec...

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Bibliographic Details
Main Authors: Sofia C. Nunes, Cristiano Ramos, Inês Santos, Cindy Mendes, Fernanda Silva, João B. Vicente, Sofia A. Pereira, Ana Félix, Luís G. Gonçalves, Jacinta Serpa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.722412/full