Multipotent Adult Progenitor Cells Suppress T Cell Activation in In Vivo Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner

Multipotent Adult Progenitor Cells Suppress T Cell Activation in In Vivo Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner

Lymphodepletion strategies are used in the setting of transplantation (including bone marrow, hematopoietic cell, and solid organ) to create space or to prevent allograft rejection and graft versus host disease. Following lymphodepletion, there is an excess of IL-7 available, and T cells that escape...

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Bibliographic Details
Main Authors: Fiona Carty, Jennifer M. Corbett, João Paulo M. C. M. Cunha, James L. Reading, Timothy I. M. Tree, Anthony E. Ting, Samantha R. Stubblefield, Karen English
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
multipotent adult progenitor cells
mesenchymal stromal cells
homeostatic proliferation
IL-7
anti-thymocyte globulin
prostaglandin E2
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00645/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2018.00645/full

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