A Viral microRNA Cluster Regulates the Expression of PTEN, p27 and of a bcl-2 Homolog.

The Epstein-Barr virus (EBV) infects and transforms B-lymphocytes with high efficiency. This process requires expression of the viral latent proteins and of the 3 miR-BHRF1 microRNAs. Here we show that B-cells infected by a virus that lacks these non-coding RNAs (Δ123) grew more slowly between day 5...

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Bibliographic Details
Main Authors: Katharina Bernhardt, Janina Haar, Ming-Han Tsai, Remy Poirey, Regina Feederle, Henri-Jacques Delecluse
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005405