Serum decoy receptor 3 is a biomarker for disease severity in nonatopic asthma patients
Decoy receptor 3 (DcR3), a soluble receptor of the tumor necrosis factor receptor superfamily, is a pleiotropic immunomodulator. The aim of this study was to investigate serum DcR3 levels in atopic and nonatopic asthma patients. Methods: The serum DcR3 levels of 70 adults with asthma and 20 healthy...
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doaj-dcd618ea1a184fb882936fa02a57c7ea2020-11-24T21:42:13ZengElsevierJournal of the Formosan Medical Association0929-66462017-01-011161495610.1016/j.jfma.2016.01.007Serum decoy receptor 3 is a biomarker for disease severity in nonatopic asthma patientsMing-Han Chen0Hung-Tsai Kan1Chun-Yu Liu2Wen-Kuang Yu3Shinn-Shing Lee4Jia-Horng Wang5Shie-Liang Hsieh6Department of Medicine, National Yang-Ming University, Taipei, TaiwanGenomics Research Center, Academia Sinica, Taipei, TaiwanDepartment of Medicine, National Yang-Ming University, Taipei, TaiwanDepartment of Medicine, National Yang-Ming University, Taipei, TaiwanSection of Allergy, Immunology, and Rheumatology, Department of Medicine, Cheng Hsin Rehabilitation Medical Center, Taipei, TaiwanCritical Care, Far Eastern Memorial Hospital, Taipei, TaiwanGenomics Research Center, Academia Sinica, Taipei, TaiwanDecoy receptor 3 (DcR3), a soluble receptor of the tumor necrosis factor receptor superfamily, is a pleiotropic immunomodulator. The aim of this study was to investigate serum DcR3 levels in atopic and nonatopic asthma patients. Methods: The serum DcR3 levels of 70 adults with asthma and 20 healthy controls were determined by enzyme-linked immunosorbent assay (ELISA). The asthma patients were divided into atopic and nonatopic subgroups, based on the presence or absence of immunoglobulin E (IgE) specific to allergen. Correlations between serum DcR3 levels and blood total-eosinophil counts, forced expiratory volume in 1 second (FEV1), FEV1/forced vital capacity (FVC), and Asthma Control Test (ACT) scores were analyzed. Results: The mean serum DcR3 level was significantly higher in asthma patients than in healthy controls (266.1 ± 60.6 pg/mL vs. 63.7 ± 21.9 pg/mL, p = 0.003), but there was no significant difference between the mean serum DcR3 level of asthma patients with atopy (37 patients) and patients without atopy (33 patients; 298.7 ± 111.2 pg/mL vs. 230.6 ± 38.5 pg/mL, p = 0.064). However, the serum DcR3 level was positively correlated with the total eosinophil count (r = 0.448, p = 0.012) and inversely correlated with the percentages of predicted FEV1, FEV1/FVC, and ACT score (r = 0.409, p = 0.018; r = −0.399, p = 0.021; and r = −0.505, p = 0.003, respectively) in nonatopic asthma patients, but not in atopic patients. Conclusion: High serum DcR3 levels are associated with disease severity in nonatopic asthma patients, which suggests that DcR3 is a potential biomarker that can be used to predict the severity of nonatopic asthma.http://www.sciencedirect.com/science/article/pii/S0929664616000486ACT scoreasthmadecoy receptor 3FEV1total eosinophil count |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ming-Han Chen Hung-Tsai Kan Chun-Yu Liu Wen-Kuang Yu Shinn-Shing Lee Jia-Horng Wang Shie-Liang Hsieh |
spellingShingle |
Ming-Han Chen Hung-Tsai Kan Chun-Yu Liu Wen-Kuang Yu Shinn-Shing Lee Jia-Horng Wang Shie-Liang Hsieh Serum decoy receptor 3 is a biomarker for disease severity in nonatopic asthma patients Journal of the Formosan Medical Association ACT score asthma decoy receptor 3 FEV1 total eosinophil count |
author_facet |
Ming-Han Chen Hung-Tsai Kan Chun-Yu Liu Wen-Kuang Yu Shinn-Shing Lee Jia-Horng Wang Shie-Liang Hsieh |
author_sort |
Ming-Han Chen |
title |
Serum decoy receptor 3 is a biomarker for disease severity in nonatopic asthma patients |
title_short |
Serum decoy receptor 3 is a biomarker for disease severity in nonatopic asthma patients |
title_full |
Serum decoy receptor 3 is a biomarker for disease severity in nonatopic asthma patients |
title_fullStr |
Serum decoy receptor 3 is a biomarker for disease severity in nonatopic asthma patients |
title_full_unstemmed |
Serum decoy receptor 3 is a biomarker for disease severity in nonatopic asthma patients |
title_sort |
serum decoy receptor 3 is a biomarker for disease severity in nonatopic asthma patients |
publisher |
Elsevier |
series |
Journal of the Formosan Medical Association |
issn |
0929-6646 |
publishDate |
2017-01-01 |
description |
Decoy receptor 3 (DcR3), a soluble receptor of the tumor necrosis factor receptor superfamily, is a pleiotropic immunomodulator. The aim of this study was to investigate serum DcR3 levels in atopic and nonatopic asthma patients.
Methods: The serum DcR3 levels of 70 adults with asthma and 20 healthy controls were determined by enzyme-linked immunosorbent assay (ELISA). The asthma patients were divided into atopic and nonatopic subgroups, based on the presence or absence of immunoglobulin E (IgE) specific to allergen. Correlations between serum DcR3 levels and blood total-eosinophil counts, forced expiratory volume in 1 second (FEV1), FEV1/forced vital capacity (FVC), and Asthma Control Test (ACT) scores were analyzed.
Results: The mean serum DcR3 level was significantly higher in asthma patients than in healthy controls (266.1 ± 60.6 pg/mL vs. 63.7 ± 21.9 pg/mL, p = 0.003), but there was no significant difference between the mean serum DcR3 level of asthma patients with atopy (37 patients) and patients without atopy (33 patients; 298.7 ± 111.2 pg/mL vs. 230.6 ± 38.5 pg/mL, p = 0.064). However, the serum DcR3 level was positively correlated with the total eosinophil count (r = 0.448, p = 0.012) and inversely correlated with the percentages of predicted FEV1, FEV1/FVC, and ACT score (r = 0.409, p = 0.018; r = −0.399, p = 0.021; and r = −0.505, p = 0.003, respectively) in nonatopic asthma patients, but not in atopic patients.
Conclusion: High serum DcR3 levels are associated with disease severity in nonatopic asthma patients, which suggests that DcR3 is a potential biomarker that can be used to predict the severity of nonatopic asthma. |
topic |
ACT score asthma decoy receptor 3 FEV1 total eosinophil count |
url |
http://www.sciencedirect.com/science/article/pii/S0929664616000486 |
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