JNK1 and 2 play a negative role in reprogramming to pluripotent stem cells by suppressing Klf4 activity

JNK1 and 2 play a negative role in reprogramming to pluripotent stem cells by suppressing Klf4 activity

Embryonic stem (ES) cells are pluripotent cells with the capacity for unlimited self-renewal or differentiation. Inhibition of MAPK pathways enhances mouse ES cell pluripotency characteristics. Compared to wildtype ES cells, jnk2−/− ES cells displayed a much higher growth rate. To determine whether...

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Bibliographic Details
Main Authors: Ke Yao, Myoung Ok Ki, Hanyong Chen, Yong-Yeon Cho, Sung-Hyun Kim, Dong Hoon Yu, Sung-Young Lee, Kun-Yeong Lee, Kibeom Bae, Cong Peng, Do Young Lim, Ann M. Bode, Zigang Dong
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506113001554

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http://www.sciencedirect.com/science/article/pii/S1873506113001554

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