Photoacoustic tomography for human musculoskeletal imaging and inflammatory arthritis detection
With the capability of assessing high resolution optical contrast in soft tissues, photoacoustic imaging (PAI) can offer valuable structural and functional information of human joints, and hold potential for diagnosis and treatment monitoring of inflammatory arthritis. Recent studies have demonstrat...
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doaj-dd70fc820471424d97fff835777614602020-11-25T01:22:02ZengElsevierPhotoacoustics2213-59792018-12-01128289Photoacoustic tomography for human musculoskeletal imaging and inflammatory arthritis detectionJanggun Jo0Chao Tian1Guan Xu2Jeffrey Sarazin3Elena Schiopu4Girish Gandikota5Xueding Wang6Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, United StatesCollege of Engineering Science, University of Science and Technology of China, Hefei, Anhui 230026, ChinaDepartment of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109, United StatesDivision of Rheumatology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109, United StatesDivision of Rheumatology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109, United StatesDepartment of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Corresponding author.Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, United States; Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Corresponding author at: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, United States.With the capability of assessing high resolution optical contrast in soft tissues, photoacoustic imaging (PAI) can offer valuable structural and functional information of human joints, and hold potential for diagnosis and treatment monitoring of inflammatory arthritis. Recent studies have demonstrated that PAI can map 2D and 3D morphology of the cartilage, synovium, vascularity, and bone tissue in human peripheral joints. Initial trials with patients affected by inflammatory arthritis have also suggested that PAI can detect the hemodynamic properties in articular tissues as well as their changes due to active inflammation. This review focuses on the recent progress in technical development of PAI for human musculoskeletal imaging and inflammation detection. PAI can provide non-invasive and non-ionizing serial measurements for monitoring of therapeutic interventions with the potential for higher sensitivity than existing imaging modalities such as ultrasound. However, further investigation is needed to validate the value of PAI in rheumatology clinical settings. Keywords: Photoacoustic tomography, Human joint, Inflammatory arthritishttp://www.sciencedirect.com/science/article/pii/S2213597918300065 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Janggun Jo Chao Tian Guan Xu Jeffrey Sarazin Elena Schiopu Girish Gandikota Xueding Wang |
spellingShingle |
Janggun Jo Chao Tian Guan Xu Jeffrey Sarazin Elena Schiopu Girish Gandikota Xueding Wang Photoacoustic tomography for human musculoskeletal imaging and inflammatory arthritis detection Photoacoustics |
author_facet |
Janggun Jo Chao Tian Guan Xu Jeffrey Sarazin Elena Schiopu Girish Gandikota Xueding Wang |
author_sort |
Janggun Jo |
title |
Photoacoustic tomography for human musculoskeletal imaging and inflammatory arthritis detection |
title_short |
Photoacoustic tomography for human musculoskeletal imaging and inflammatory arthritis detection |
title_full |
Photoacoustic tomography for human musculoskeletal imaging and inflammatory arthritis detection |
title_fullStr |
Photoacoustic tomography for human musculoskeletal imaging and inflammatory arthritis detection |
title_full_unstemmed |
Photoacoustic tomography for human musculoskeletal imaging and inflammatory arthritis detection |
title_sort |
photoacoustic tomography for human musculoskeletal imaging and inflammatory arthritis detection |
publisher |
Elsevier |
series |
Photoacoustics |
issn |
2213-5979 |
publishDate |
2018-12-01 |
description |
With the capability of assessing high resolution optical contrast in soft tissues, photoacoustic imaging (PAI) can offer valuable structural and functional information of human joints, and hold potential for diagnosis and treatment monitoring of inflammatory arthritis. Recent studies have demonstrated that PAI can map 2D and 3D morphology of the cartilage, synovium, vascularity, and bone tissue in human peripheral joints. Initial trials with patients affected by inflammatory arthritis have also suggested that PAI can detect the hemodynamic properties in articular tissues as well as their changes due to active inflammation. This review focuses on the recent progress in technical development of PAI for human musculoskeletal imaging and inflammation detection. PAI can provide non-invasive and non-ionizing serial measurements for monitoring of therapeutic interventions with the potential for higher sensitivity than existing imaging modalities such as ultrasound. However, further investigation is needed to validate the value of PAI in rheumatology clinical settings. Keywords: Photoacoustic tomography, Human joint, Inflammatory arthritis |
url |
http://www.sciencedirect.com/science/article/pii/S2213597918300065 |
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