Genomic identification of sarcoma radiosensitivity and the clinical implications for radiation dose personalization

Genomic identification of sarcoma radiosensitivity and the clinical implications for radiation dose personalization

Background: Soft-tissue sarcomas (STS) are heterogeneous with variable response to radiation therapy (RT). Utilizing the radiosensitivity index (RSI) we estimated the radiobiologic ratio of lethal to sublethal damage (α/β), genomic-adjusted radiation dose(GARD), and in-turn a biological effective ra...

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Bibliographic Details
Main Authors: George Yang, Zhigang Yuan, Kamran Ahmed, Eric A. Welsh, William J. Fulp, Ricardo J. Gonzalez, John E. Mullinax, Douglas Letson, Marilyn Bui, Louis B. Harrison, Jacob G. Scott, Javier F. Torres-Roca, Arash O. Naghavi
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Translational Oncology
Subjects:
Radiation therapy
Radiosensitivity
Genomic-adjusted radiation dose
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321001571

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http://www.sciencedirect.com/science/article/pii/S1936523321001571

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